Neglected disease research and development: how much are we really spending

submitted by: mparkinson
The need for new pharmaceutical tools to prevent and treat neglected diseases is widely accepted. The creation of a vaccine for HIV/AIDS, more effective diagnostics for tuberculosis (TB), and better treatments for leishmaniasis and sleeping sickness would greatly improve health in the developing world in line with the United Nations Millennium Development Goals. However, funders wishing to invest in this vitally important area currently face an information gap. There is little consensus on...
Authors: Mary Moran, Javier Guzman, Anne-laure Ropars, Alina Mcdonald, Nicole Jameson, Brenda Omune, Sam Ryan, Lindsey Wu

Cell Organization & Cell Motility by Julie Theriot - Part 1: Cell Motility and the Cytoskeleton: Protein Polymers Crawling Cells and Comet Tails (43:53)

submitted by: video_collector
This lecture covers the biochemical basis of actin-based motility (focusing on the pathogen Listeria as a model system for this process), the biophysical mechanism of polymerization-based force generation, and an evolutionary perspective of cell shape in prokaryotes and eukaryotes. The first part covers our understanding of how cells use the actin cytoskeleton to crawl. The pathogenic bacteria Listeria (which causes food poisoning) uses the actin cytoskeleton to propel itself in the...

Calcium Channels

submitted by: alex01

Dr. Catterall describes autoinhibitory control of cardiac L-type cardiac calcium channels by protein
phosphorylation and macromolecular signaling as well as regulation of P/Q type calcium currents in
neurons. His research suggests novel targets for drugs affecting cardiovascular or central nervous
systems.

Sperm Selection for In Vitro Fertilization

submitted by: alex01

G. Huszar, MD - G. Huszar developed hyaluronic acid (HA) binding test for sperm selection for in vitro fertilization. The test allows better assessment of sperm maturity than previously used motility test. Dr. Huszar discusses also safety of cryopreservation of sperms and potential for male contraceptive drugs.

Obesity and Metabolic Syndrome

submitted by: alex01

F. X. Pi-Sunyer, MD defines metabolic syndrome and obesity and discusses the design and preliminary results of the Look AHEAD trial involving the importance of life style modification in the prevention of cardiovascular complications in patients with type II diabetes. Current and potential approaches to the therapy of obesity include modulators of the endocannabinoid system, drugs affecting free fatty acid synthesis and metabolism as drugs capable of increasing metabolic expenditure.

How Drosha and Dicer work in RNA interference

submitted by: mdanderson

Animated demonstration on how Dicer and Drosha work in RNA interference.