Scripps Translational Science Institute - Welcome Video

submitted by: STSI-Admin

The Scripps Translational Science Institute (STSI), in conjunction with the National Institutes of Health (NIH) Translational Science Award (CTSA) Consortium is transforming how clinical and translational research is conducted, ultimately enabling researchers to provide new treatments more efficiently and quickly to patients. For more information see: http://www.stsiweb.org/

Drug Discovery for Alzheimer's Disease

submitted by: alex01

Gregory Rose from PharmExperts.com interviews J. Buccafusco (Medical College of Georgia, Augusta, GA) about his development of new anti-Altzheimer drugs, designed to act by multiple mechanisms to improve congnition. Desensitization of nicotinic receptors is one of the novel approaches proposed by Buccafusco. Three of his compounds are currently in advanced preclinical evaluation.

Neglected disease research and development: how much are we really spending

submitted by: mparkinson
The need for new pharmaceutical tools to prevent and treat neglected diseases is widely accepted. The creation of a vaccine for HIV/AIDS, more effective diagnostics for tuberculosis (TB), and better treatments for leishmaniasis and sleeping sickness would greatly improve health in the developing world in line with the United Nations Millennium Development Goals. However, funders wishing to invest in this vitally important area currently face an information gap. There is little consensus on...
Authors: Mary Moran, Javier Guzman, Anne-laure Ropars, Alina Mcdonald, Nicole Jameson, Brenda Omune, Sam Ryan, Lindsey Wu

Cell Organization & Cell Motility by Julie Theriot - Part 1: Cell Motility and the Cytoskeleton: Protein Polymers Crawling Cells and Comet Tails (43:53)

submitted by: video_collector
This lecture covers the biochemical basis of actin-based motility (focusing on the pathogen Listeria as a model system for this process), the biophysical mechanism of polymerization-based force generation, and an evolutionary perspective of cell shape in prokaryotes and eukaryotes. The first part covers our understanding of how cells use the actin cytoskeleton to crawl. The pathogenic bacteria Listeria (which causes food poisoning) uses the actin cytoskeleton to propel itself in the...

Calcium Channels

submitted by: alex01

Dr. Catterall describes autoinhibitory control of cardiac L-type cardiac calcium channels by protein
phosphorylation and macromolecular signaling as well as regulation of P/Q type calcium currents in
neurons. His research suggests novel targets for drugs affecting cardiovascular or central nervous
systems.

Sperm Selection for In Vitro Fertilization

submitted by: alex01

G. Huszar, MD - G. Huszar developed hyaluronic acid (HA) binding test for sperm selection for in vitro fertilization. The test allows better assessment of sperm maturity than previously used motility test. Dr. Huszar discusses also safety of cryopreservation of sperms and potential for male contraceptive drugs.