Adhesion, Signaling and Cancer by Mary C. Beckerle, July 2007 - Part 1: Understanding Cancer From Its Beginnings (36:04)

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Cell-substratum adhesion is mediated by integrins, a family of transmembrane, heterodimeric, extracellular matrix receptors that are concentrated at focal adhesions. Integin engagement influences a variety of signaling pathways and regulates cell behaviors including motility, proliferation, and survival. Disturbance of normal integrin function is associated with a variety of pathologic conditions including cancer. In the first segment of my seminar, I provide a broad overview of the cancer...

Imatinib (Gleevec) as a Paradigm of Targeted Cancer Therapies by Brian Druker, March 2007 - Part 1: Chronic Myeloid Leukemia (CML) and Imatinib (33:54)

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Imatinib (Gleevec) has become a paradigm for targeted cancer therapies. The first part of this lecture will describe the clinical features and the molecular pathogenesis of the disease for which imatinib was developed, chronic myeloid leukemia (CML). This overview will trace the history of the identification of the target of imatinib, BCR-ABL. The preclinical development of the BCR-ABL kinase inhibitor, imatinib and highly successful clinical trials of this agent for patients with CML will...

Stem Cells: Biology and Promise for Regenerative Medicine by Elaine Fuchs, Jan. 2007 - Part 1: Introduction to Stem Cells and Ethical Issues (35:11)

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During embryogenesis, a single fertilized oocyte gives rise to a multicellular organism whose cells and tissues have adopted differentiated characteristics or fates to perform the specified functions of each organ of the body. As embryos develop, cells that have acquired their particular fate proliferate, enabling tissues and organs to grow. Even after an animal is fully grown, however, many tissues and organs maintain a process known as homeostasis, where as cells die, either by natural...

Genes and Cells that Determine the Lifespan of C. elegans - Part 1: An Evolutionarily-Conserved Regulatory System for Aging (42:46)

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Once it was thought that aging was just a random and haphazard process. Instead, the rate of aging turns out to be subject to regulation by transcription factors that respond to hormones and other signals. In the nematode C. elegans, in which many key discoveries about aging were first made, the aging process is subject to regulation by food intake, sensory perception, and signals from the reproductive system. Changing genes and cells that affect aging can lengthen lifespan by six fold, and...

Polyketide Biosynthesis: The Erythromycin Example - Part 1: Overview of Polyketides and Polyketide Biosynthesis (34:10)

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In the first part, an overview of polyketides and polyketide biosynthesis is presented. A rationale for investigating polyketide biosynthesis is also presented.

For further informaton see: http://www.ascb.org/ibioseminars/Khosla/Khosla1.cfm

Part V - Business Approaches to Implement CSR

submitted by: asantos
6 CORPORATE STRATEGIES TO IMPLEMENT CSR 6.1 Context A number of variables affect the strategy that a given company chooses to implement its CSR, including its structure, size, culture and business strategy. CSR strategies might also be affected by how close they are to the core business or the proximity that it demands from the community that has been affected. Defining the appropriate strategy for CSR is one of the roles that can be played by the designer since he/she can have the...
Authors: Aguinaldo dos Santos, Carlo Vezzoli, Sara Cortesi