Telomeres and Telomerase: Their Implications in Human Health and Disease

submitted by: scivee-team
Telomerase, a specialized ribonucleprotein reverse transcriptase, is important for long-term eukaryotic cell proliferation and genomic stability, because it replenishes the DNA at telomeres. Thus depending on cell type telomerase partially or completely (depending on cell type) counteracts the progressive shortening of telomeres that otherwise occurs. Telomerase is highly active in many human malignancies, and a potential target for anti-cancer approaches. Furthermore, recent collaborative...

Developmental Biology of a Simple Organism: Part 3: Stochasticity and Cell Fate (25:03)

submitted by: scivee-team

Part III presents research showing that B. subtilis uses a bet hedging strategy for coping with uncertainty.

Developmental Biology of a Simple Organism: Part 2: New Research on Multicellularity (18:13)

submitted by: scivee-team

Part II presents research on the capacity of B. subtilis cells to form architecturally complex communities.

Sex and Smell: Molecular Biology of Pheromone Perception: Part 3: Sex-Specificity of Pheromone Responses (30:39)

submitted by: scivee-team

Pheromones have evolved to signal the sex and the dominance status of animals and to promote social and mating rituals. In this lecture, I discuss the how pheromone sensing operates in mammals. I will discuss the molecular biology of the chemosensory receptors that are involved the first steps of pheromone sensing. At a higher level of complexity, I will discuss a distinct olfactory structure called the vomeronasal organ (VNO) and how it contributes to sex-specific behavioral responses.

Sex and Smell: Part 2: Molecular Biology of Pheromone Perception (43:43)

submitted by: scivee-team

Pheromones have evolved to signal the sex and the dominance status of animals and to promote social and mating rituals. In this lecture, I discuss the how pheromone sensing operates in mammals. I will discuss the molecular biology of the chemosensory receptors that are involved the first steps of pheromone sensing. At a higher level of complexity, I will discuss a distinct olfactory structure called the vomeronasal organ (VNO) and how it contributes to sex-specific behavioral responses.

Cell-Cell Communication in Bacteria: Part 2: Vibrio Cholerae Quorum Sensing and Developing Novel Antibiotics (19:49)

submitted by: scivee-team
Bacteria, primitive single-celled organisms, communicate with chemical languages that allow them to synchronize their behavior and thereby act as enormous multi-cellular organisms. This process is called quorum sensing and it enables bacteria to successfully infect and cause disease in plants, animals, and humans. Investigations of the molecular mechanisms underlying quorum sensing are leading to the development of novel strategies to interfere with quorum sensing. These strategies form the...