Once it was thought that aging was just a random and haphazard process. Instead, the rate of aging turns out to be subject to regulation by transcription factors that respond to hormones and other signals. In the nematode C. elegans, in which many key discoveries about aging were first made, the aging process is subject to regulation by food intake, sensory perception, and signals from the reproductive system. Changing genes and cells that affect aging can lengthen lifespan by six fold, and...

In the first part, an overview of polyketides and polyketide biosynthesis is presented. A rationale for investigating polyketide biosynthesis is also presented.

For further informaton see: http://www.ascb.org/ibioseminars/Khosla/Khosla1.cfm

6 CORPORATE STRATEGIES TO IMPLEMENT CSR 6.1 Context A number of variables affect the strategy that a given company chooses to implement its CSR, including its structure, size, culture and business strategy. CSR strategies might also be affected by how close they are to the core business or the proximity that it demands from the community that has been affected. Defining the appropriate strategy for CSR is one of the roles that can be played by the designer since he/she can have the...

Stem cell expert Rudolph Jaenisch is interviewed by Richard Sever of Cold Spring Harbor Laboratory following his keynote lecture at the 2008 Cold Spring Harbor Symposium on Quantitative Biology

4 DRIVERS/BARRIERS FOR CSR In order to allow a designer to understand his/her role within a CSR initiative it is important he/she understand the various motivations that could drive a business (and a businessman) to invest company assets into social responsibilities. It is important to call attention to the fact that these CSR drivers could also be understood as barriers for CSR on those situations when they are absent. Hence, the focus of the designer on his/her creative process would...

2 CSR BENEFITS FOR THE COMPANY 2.1 Increase in Profits A report released by Goldman Sachs (GSSustain, 2007) on six industrial sectors – energy, mining, steel, food, beverages and media – found that companies considered leaders in implementing environmental, social and governance policies designed to create sustained competitive advantage had outperformed the overall stock market by 25 per cent since August 2005. Within their own sectors, 72 per cent of these leading companies had...