Abstract: BACKGROUND: Ascertainment of potential subjects has been a longstanding problem in clinical research. Various methods have been proposed, including using data in electronic health records. However, these methods typically suffer from scaling effects-some methods work well for large cohorts; others work for small cohorts only. OBJECTIVE: We propose a method that provides a simple identification of pre-research cohorts and relies on data available in most states in the USA: merged...

Kinetic models enable nutrient needs and kinetic behaviors to be quantified and provide mechanistic insights into metabolism. Therefore, we modeled and quantified the kinetics, bioavailability, and metabolism of RRR-alpha-tocopherol in 12 healthy adults. Six men and 6 women, aged 27 +/- 6 y, each ingested 1.81 nmol of 14C-RRR-alpha-tocopherol; each dose had 3.70 kBq of 14C. Complete collections of urine and feces were made over the first 21d from dosing. Serial blood samples were drawn over...

Dr. Terry Therneau, a Professor of Biostatistics at Mayo Clinic in Rochester, MN, discusses his article appearing online first and in the November 2012 issue of Mayo Clinic Proceedings, placing the surprising outcome among the statistics discovered in the study into perspective. Available at: http://www.mayoclinicproceedings.org/article/ S0025-6196(12)00634-9/fulltext

Dr. Keith Swetz, a Palliative Medicine Physician in the Division of General Internal Medicine at Mayo Clinic in Rochester, MN, discusses his article appearing in the November 2012 issue of Mayo Clinic Proceedings, highlighting the key current points of palliative medicine including ethics, symptom management, and pain.
Available at: http://www.mayoclinicproceedings.org/article/S0025-6196(12)00815-4/fulltext

Dr. Robert Kyle, professor of medicine, laboratory medicine and pathology, at Mayo Clinic in Rochester, MN, discusses his article appearing online first and in the November 2012 issue of Mayo Clinic Proceedings, where he defines MGUS and explains its role in the development of multiple myeloma and other blood disorders.
Available at: http://www.mayoclinicproceedings.org/article/S0025-6196(12)00634-9/fulltext

Dr. Anthony Kim, Vascular Neurologist and Assistant Professor of Neurology from the University of California in San Francisco discusses his article appearing in the November 2012 issue of Mayo Clinic Proceedings on the development of an evidence-based way to identify the difference between common and serious causes of dizziness in the emergency room setting. Available at: http://www.mayoclinicproceedings.org/article/ S0025-6196(12)00817-8/fulltext