The Surprising World of Prion Biology--A New Mechanism of Inheritance: Part II (26:08)

submitted by: scivee-team
Part II: In the case of the yeast prion [PSI], the misfolding of the Sup35 protein results in a simple change in metabolism. When misfolded Sup35 is passed from mother cells to their daughters, this metabolic change is inherited. This unusual genetic mechanism changes the organism in a heritable way due to a self-perpetuating change in protein conformation with no change in its DNA. The mechanism of epigenetic inheritance we have delineated provides a one-step process for the acquisition of...

The Vertebrate Retina: Structure, Function, and Evolution: Part 3: The Evolution of Trichromatic Color Vision (43:26)

submitted by: scivee-team

The third lecture describes recent work on the evolution of trichromatic color vision in humans and our primate relatives.

The Vertebrate Retina: Structure, Function, and Evolution: Part 2: Human Color Vision and its Variations (44:33)

submitted by: scivee-team

The second lecture focuses on the photoreceptors that mediate human color vision and the molecular basis for the common inherited anomalies of color vision.

The Vertebrate Retina: Structure, Function, and Evolution: Part 1B: Photoreceptors and Image Processing (35:22)

submitted by: scivee-team

In this set of lectures, Jeremy Nathans explores the molecular mechanisms within the retina that mediate the first steps in vision. The first lecture focuses on the structure of the light sensing receptors, the intracellular signals that are triggered by light absorption, and the ways in which the retina extracts information from a complex scene.

Telomeres and Telomerase: Their Implications in Human Health and Disease: Part 3: Stress, Telomeres and Telomerase in Humans (45:58)

submitted by: scivee-team
Telomerase, a specialized ribonucleprotein reverse transcriptase, is important for long-term eukaryotic cell proliferation and genomic stability, because it replenishes the DNA at telomeres. Thus depending on cell type telomerase partially or completely (depending on cell type) counteracts the progressive shortening of telomeres that otherwise occurs. Telomerase is highly active in many human malignancies, and a potential target for anti-cancer approaches. Furthermore, recent collaborative...

Telomeres and Telomerase: Their Implications in Human Health and Disease

submitted by: scivee-team
Telomerase, a specialized ribonucleprotein reverse transcriptase, is important for long-term eukaryotic cell proliferation and genomic stability, because it replenishes the DNA at telomeres. Thus depending on cell type telomerase partially or completely (depending on cell type) counteracts the progressive shortening of telomeres that otherwise occurs. Telomerase is highly active in many human malignancies, and a potential target for anti-cancer approaches. Furthermore, recent collaborative...