San Diego Science Festival -- Nifty Fifty -- Dr. Javier Movellan

submitted by: sdscienccefestival

Dr. Javier Movellan speaks to students of Sacred Heart Middle School about machine intelligence.

San Diego Science Festival -- Lunch with a Laureate -- Dr. Kurt Withrich

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Nobel Laureate Kurt Wuthrich joins students of High Tech High - Chula Vista in an informal Q&A.

Stem Cells: Biology and Promise for Regenerative Medicine: Part 2: Tapping the Potential of Adult Stem Cells (1:17:03)

submitted by: scivee-team
Stem cells have both the capacity to self-renew, that is, to divide and create additional stem cells, and also to differentiate along a specified molecular pathway. Embryonic stem cells are very nearly totipotent, reserving the elite privileges of choosing among most if not all of the differentiation pathways that specify the animal. In contrast, stem cells that reside within an adult organ or tissue have more restricted options, often able to select a differentiation program from only a few...

Imatinib (Gleevec) as a Paradigm of Targeted Cancer Therapies: Part 3: Extending the Imatinib Paradigm (22:09)

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The lessons learned from the clinical trials of imatinib will be reviewed in this section. This will include examples of where imatinib has or has not worked, analysis of target expression versus activation and a discussion of how the success of imatinib can be translated to other malignancies. The section concludes with what this means for research to control or cure cancer in the coming decades.

Imatinib (Gleevec) as a Paradigm of Targeted Cancer Therapies: Part 2: Imatinib Resistance and Other Diseases Targeted by Imatinib (25:12)

submitted by: scivee-team
Although the majority of patients with CML respond well to imatinib, a minority of patients have relapsed. This part of the lecture will cover what has been learned about mechanisms of relapse and how this information has been translated into new therapies for patients with imatinib resistance. Although imatinib is a relatively specific inhibitor of the ABL kinase, a couple of other kinases, KIT and the platelet derived growth factor receptor are also inhibited by imatinib. This use of this...

Adhesion, Signaling and Cancer: Part 3: Focal Adhesions as Stress Sensors (30:57)

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In the third segment of my seminar, I address a new frontier in cell biology, that is how cells respond to mechanical information. Cells and tissues are exposed to physical forces in vivo and excessive mechanical stress leads to a variety of pathological consequences. I describe a system for exposing cells to controlled mechanical stress and discuss the stretch response. We have discovered that the focal adhesion protein, zyxin, is exquisitely sensitive to mechanical stimulation and is...