Trudy Forte presents "Drugs for Brain Tumors"

submitted by: video_collector

Trudy Forte discusses her work developing nano-sized low-density lipoprotein (LDL) particles that can be used as a safe and effective means of delivering anticancer drugs to brain tumors, particularly the most common malignant brain tumor in adults and one of the deadliest forms of cancer. Series: Lawrence Berkeley National Laboratory Summer Lecture Series [Health and Medicine] [Science] [Show ID: 13002]

Interview with Computational Biologist and SciVee Cofounder Phil Bourne

linked profile(s): simont
submitted by: Phil

Prof. Simon Twigger of the Medical College of Wisconsin asked me to visit for a day in January of 2008. We started the day with this interview which Simon conducted which describes my career and interests. He kindly let us post it here. It might be of interest to anyone considering a career in computational biology as it covers one such career path which began before the field itself was established.

Dynamic Remodeling of Individual Nucleosomes Across a Eukaryotic Genome in Response to Transcriptional Perturbation

submitted by: akshayb
The eukaryotic genome is packaged as chromatin with nucleosomes comprising its basic structural unit, but the detailed structure of chromatin and its dynamic remodeling in terms of individual nucleosome positions has not been completely defined experimentally for any genome. We used ultra-high–throughput sequencing to map the remodeling of individual nucleosomes throughout the yeast genome before and after a physiological perturbation that causes genome-wide transcriptional changes....
Authors: Sushma Shivaswamy, Akshay Bhinge, Yongjun Zhao, Steven Jones, Martin Hirst, Vishwanath r Iyer

Two quick tips to stay on top of literature and other online information using Google

submitted by: simont

Behind in the literature? Losing track of valuable web pages and information you found online? This brief video shows how to use some of Google's free tools, Notebook and Reader, to help you manage these problems. You can use Google Notebook as an online scrapbook to instantly save pieces of text, web pages and even images to your own personal notebook. You can use Google Reader to help you get on top of the literature and then stay on top without any extra effort.

Moby, Legacy Apps and the Semantic Web

submitted by: nodrogluap
[Note: poor video quality lasts only for the first 30 seconds] Presentation given at the Web Services Biohackathon '08 in Tokyo, Japan 2008-02-11. It describes tools for using and providing interoperable bioinformatics Web services. This presentation followed another one outlining the (Bio)Moby protocol and its usage, see www.biomoby.org for more information. Presenter: Paul Gordon .

Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis

submitted by: mmcguckin
Background MUC2 mucin produced by intestinal goblet cells is the major component of the intestinal mucus barrier. The inflammatory bowel disease ulcerative colitis is characterized by depleted goblet cells and a reduced mucus layer, but the aetiology remains obscure. In this study we used random mutagenesis to produce two murine models of inflammatory bowel disease, characterised the basis and nature of the inflammation in these mice, and compared the pathology with human ulcerative colitis....
Authors: Heazlewood CK, Cook MC, Eri R, Price G, Tauro S, Taupin D, Thornton DJ, Png CW, Crockford TL, Cornall, RJ, Adams R, Kato M, Nelms KA, Hong NA, Florin THJ, Goodnow CC, McGuckin MA