biosights: May 13, 2013 - Ventral lamellipodia plug the gaps

submitted by: JCB
When leukocytes enter or exit the blood stream, they leave small wounds both in and between the vascular endothelial cells, which must be quickly repaired so that the endothelium can maintain its barrier function. Martinelli et al. reveal that wounding causes a loss of tension in endothelial cells, inducing the formation of ventral lamellipodia that close the holes left by transmigrating leukocytes. This biosights episode presents the paper by Martinelli et al. from the April 29, 2013, issue...

Bacterial Aerotaxis

submitted by: mhrussel

Aerotaxis is the movement of an organism in response to environmental oxygen concentrations, either towards or away from a given oxygen concentration. Many bacteria are microaerophilic meaning they prefer environments with low oxygen content. Higher or lower O2 content than the optimum are considered a repellant and bacteria will navigate towards the optimum. This animation is an overview of studying aerotaxis in motile bacteria.

Glycolysis animation

submitted by: mhrussel

Glycolysis is a determined sequence of ten reactions involving ten intermediate compounds (one of the steps involves two intermediates). The intermediates provide entry points to glycolysis. This animation features the 3D protein structures of all ten enzymes as well as the enzyme substrate and products.

20130423 - Protein Prediction 1 - Burkhard Rost - Introduction - Life, molecules, parts

submitted by: rostlab

Date: 20130423
Course: Protein Prediction 1
Title: Introduction - Life, molecules, parts
Speaker: Burkhard Rost
Audience: Computational biology students

Association of raw fruit and fruit juice consumption with blood pressure: the INTERMAP Study

submitted by: loudegri
Background: Epidemiological evidence suggests that fruit consumption may lower the risk of cardiovascular diseases through blood pressure (BP)–lowering effects; little is known on the independent effect of raw fruit and fruit juice on BP. Objective: The objective was to quantify associations of raw fruit and fruit juice consumption with BP by using cross-sectional data from the INTERnational study on MAcro/micronutrients and blood Pressure (INTERMAP) of 4680 men and women aged...
Authors: Linda Oude Griep, Jeremiah Stamler, Queenie Chan, Linda Van Horn, Lyn Steffen, Katsuyuki Miura, Hirotsugu Ueshima, Nagako Okuda, Liancheng Zhao, Martha Daviglus, Paul Elliott

Weight loss, weight maintenance, and adaptive thermogenesis

submitted by: stefancamps
Background: Diet-induced weight loss is accompanied by adaptive thermogenesis, ie, a disproportional or greater than expected reduction of resting metabolic rate (RMR). Objective: The aim of this study was to investigate whether adaptive thermogenesis is sustained during weight maintenance after weight loss. Design: Subjects were 22 men and 69 women [mean 6 SD age: 40 6 9 y; body mass index (BMI; in kg/m2): 31.9 6 3.0]. They followed a very-low-energy diet for 8 wk, followed by a...
Authors: Stefan Camps, Sanne Verhoef, Klaas Westerterp