De geschiedenis van de Pathologie, een reis door de archieven

submitted by: LUMC_PA_MD
Technologische vooruitgang in de pathologie. Een reis door de archieven. Van anatomisch theater naar “gepersonaliseerde geneeskunde”. Deze video presentatie is gemaakt ten behoeve van de promotie van Ronald van Eijk d.d. 8 mei 2013 op het proefschrift: Technological Advances in Molecular Pathology. A journey into the Archives De presentatie geeft een populair wetenschappelijk beeld van de ontwikkelingen in de Pathologie. In de loop der eeuwen zijn er vele revolutionaire, breed...

MWV Episode 72 - Jonathan Eisen - Evolvability, the Built Environment and Open Science

submitted by: MicrobeWorld
Jonathan Eisen is an evolutionary biologist, currently working at University of California, Davis and is the academic editor-in-chief of the open-access journal PLoS Biology. On this episode, Jonathan talks about "evolvability," the probability that organisms can invent new functions. To do this, he has been using genome data in conjunction with experimental information to try and understand the mechanisms by which new functions have originated. Another area of interest for Eisen is the...

A Whole-Grain–Rich Diet Reduces Urinary Excretion of Markers of Protein Catabolism and Gut Microbiota Metabolism in Healthy Men after One Week

submitted by: Alastair Ross
Epidemiological studies consistently find that diets rich in whole-grain (WG) cereals lead to decreased risk of disease compared with refined grain (RG)-based diets. Aside from a greater amount of fiber and micronutrients, possible mechanisms for why WGs may be beneficial for health remain speculative. In an exploratory, randomized, researcherblinded, crossover trial, we measured metabolic profile differences between healthy participants eating a diet based on WGs compared with a diet...
Authors: Alastair Ross, Emma Pere-Trépat, Ivan Montoliu, Francois-Pierre Martin, Sebastiano Collino, Sofia Moco, Jean-Philippe Godin, Marilyn Cléroux, Philippe Guy, Isabelle Breton, Rodrigo Bibiloni, Anita Thorimbert, Isabelle Tavazzi, Lionel Tornier, Aude Bebuis, Stephen Bruce, Maurice Beaumont, Laurent-Bernard Fay, Sunil Kochhar

DNA methylation potential: dietary intake and blood concentrations of one-carbon metabolites and cofactors in rural African women

submitted by: enphpdom
Background: Animal models show that periconceptional supplementation with folic acid, vitamin B-12, choline, and betaine can induce differences in offspring phenotype mediated by epigenetic changes in DNA. In humans, altered DNA methylation patterns have been observed in offspring whose mothers were exposed to famine or who conceived in the Gambian rainy season. Objective: The objective was to understand the seasonality of DNA methylation patterns in rural Gambian women. We studied natural...
Authors: P Dominguez-Salas, AM Prentice

Grape Powder Supplementation Prevents Oxidative Stress–Induced Anxiety-Like Behavior, Memory Impairment, and High Blood Pressure in Rats

submitted by: ssalim
We examined whether or not grape powder treatment ameliorates oxidative stress–induced anxiety-like behavior, memory impairment, and hypertension in rats. Oxidative stress in Sprague-Dawley rats was produced by using L-buthionine- (S,R)-sulfoximine (BSO). Four groups of rats were used: 1) control (C; injected with vehicle and provided with tap water), 2) grape powder–treated (GP; injected with vehicle and provided for 3 wk with 15 g/L grape powder dissolved in tap water), 3)...
Authors: Farida Allam, An Dao, Gaurav Chugh, Ritu Bohat, Faizan Jafri, Gaurav Patki, Christopher Mowrey, Mohammad Asghar, Karim Alkadhi, Samina Salim

Factors predicting overweight in US kindergarteners

submitted by: glflor
BACKGROUND: Childhood overweight is a substantial public-health problem, but little is known about predictors of early childhood overweight. OBJECTIVE: We aimed to identify factors-alone and in combination-that predict kindergarten overweight. DESIGN: We analyzed nationally representative data from the Early Childhood Longitudinal Study-Birth Cohort, a longitudinal cohort study of 6800 children followed from birth through kindergarten. Multivariable logistic regression and recursive...
Authors: Glenn Flores, Hua Lin