biosights: June 10, 2013 - Netrin Throws Anchor Cells into the Breach

submitted by: JCB
Cell invasion through basement membranes is crucial for both normal development and cancer metastasis but relatively little is known about the process because it is difficult to observe in vivo. By imaging the invasion of anchor cells during C. elegans development, Hagedorn et al. reveal that, after invadopodia-like structures form an initial breach in the basement membrane, localized netrin signaling helps generate a stable invasive protrusion that widens the gap and directs the cell across...

Echogram of the Red Sea

submitted by: apryl
This is a short clip intended for use at the KAUST SIGGRAPH booth in a series of video loops played during the convention. 62,000+ pixels wide, this image can be viewed in full resolution on the 40 Gigapixel tiled display wall at KAUST Visualization Laboratory. It is also annotated with sound clips that describe specific areas of the dataset as you bring them into view. Data provided by: Dr. Stein Kaartvedt, KAUST Professor, Marine Science Associate Director, Red Sea Research Center...

De geschiedenis van de Pathologie, een reis door de archieven

submitted by: LUMC_PA_MD
Technologische vooruitgang in de pathologie. Een reis door de archieven. Van anatomisch theater naar “gepersonaliseerde geneeskunde”. Deze video presentatie is gemaakt ten behoeve van de promotie van Ronald van Eijk d.d. 8 mei 2013 op het proefschrift: Technological Advances in Molecular Pathology. A journey into the Archives De presentatie geeft een populair wetenschappelijk beeld van de ontwikkelingen in de Pathologie. In de loop der eeuwen zijn er vele revolutionaire, breed...

MWV Episode 72 - Jonathan Eisen - Evolvability, the Built Environment and Open Science

submitted by: MicrobeWorld
Jonathan Eisen is an evolutionary biologist, currently working at University of California, Davis and is the academic editor-in-chief of the open-access journal PLoS Biology. On this episode, Jonathan talks about "evolvability," the probability that organisms can invent new functions. To do this, he has been using genome data in conjunction with experimental information to try and understand the mechanisms by which new functions have originated. Another area of interest for Eisen is the...

A Whole-Grain–Rich Diet Reduces Urinary Excretion of Markers of Protein Catabolism and Gut Microbiota Metabolism in Healthy Men after One Week

submitted by: Alastair Ross
Epidemiological studies consistently find that diets rich in whole-grain (WG) cereals lead to decreased risk of disease compared with refined grain (RG)-based diets. Aside from a greater amount of fiber and micronutrients, possible mechanisms for why WGs may be beneficial for health remain speculative. In an exploratory, randomized, researcherblinded, crossover trial, we measured metabolic profile differences between healthy participants eating a diet based on WGs compared with a diet...
Authors: Alastair Ross, Emma Pere-Trépat, Ivan Montoliu, Francois-Pierre Martin, Sebastiano Collino, Sofia Moco, Jean-Philippe Godin, Marilyn Cléroux, Philippe Guy, Isabelle Breton, Rodrigo Bibiloni, Anita Thorimbert, Isabelle Tavazzi, Lionel Tornier, Aude Bebuis, Stephen Bruce, Maurice Beaumont, Laurent-Bernard Fay, Sunil Kochhar

DNA methylation potential: dietary intake and blood concentrations of one-carbon metabolites and cofactors in rural African women

submitted by: enphpdom
Background: Animal models show that periconceptional supplementation with folic acid, vitamin B-12, choline, and betaine can induce differences in offspring phenotype mediated by epigenetic changes in DNA. In humans, altered DNA methylation patterns have been observed in offspring whose mothers were exposed to famine or who conceived in the Gambian rainy season. Objective: The objective was to understand the seasonality of DNA methylation patterns in rural Gambian women. We studied natural...
Authors: P Dominguez-Salas, AM Prentice