biosights: July 8, 2013 - Vinculin delivers a clutch performance

submitted by: JCB
At the leading edge of migrating cells, actin assembly and membrane protrusion are closely coupled with the formation of integrin-based focal adhesions that attach to the extracellular matrix. Thievessen et al. reveal that the focal adhesion protein vinculin acts as part of a molecular clutch that engages actin flow to coordinate actin and focal adhesion dynamics. This biosights episode presents the paper by Thievessen et al. from the July 8, 2013, issue of The Journal of Cell Biology and...

Diet, microbiota, and microbial metabolites in colon cancer risk in rural Africans and African Americans

submitted by: sjokeefe
Background: Epidemiologic studies have suggested that most cases of sporadic colon cancer can be attributed to diet. The recognition that colonic microbiota have a major influence on colonic health suggests that they might mediate colonic carcinogenesis. Objective: To examine the hypothesis that the influence of diet on colon cancer risk is mediated by the microbiota through their metabolites, we measured differences in colonic microbes and their metabolites in African Americans with a...
Authors: Junhai Ou, Franck Carbonero, Erwin G Zoetendal, James P DeLany, Mei Wang, Keith Newton, H Rex Gaskins, Stephen JD O’Keefe

biosights: June 10, 2013 - Netrin Throws Anchor Cells into the Breach

submitted by: JCB
Cell invasion through basement membranes is crucial for both normal development and cancer metastasis but relatively little is known about the process because it is difficult to observe in vivo. By imaging the invasion of anchor cells during C. elegans development, Hagedorn et al. reveal that, after invadopodia-like structures form an initial breach in the basement membrane, localized netrin signaling helps generate a stable invasive protrusion that widens the gap and directs the cell across...

Echogram of the Red Sea

submitted by: apryl
This is a short clip intended for use at the KAUST SIGGRAPH booth in a series of video loops played during the convention. 62,000+ pixels wide, this image can be viewed in full resolution on the 40 Gigapixel tiled display wall at KAUST Visualization Laboratory. It is also annotated with sound clips that describe specific areas of the dataset as you bring them into view. Data provided by: Dr. Stein Kaartvedt, KAUST Professor, Marine Science Associate Director, Red Sea Research Center...

De geschiedenis van de Pathologie, een reis door de archieven

submitted by: LUMC_PA_MD
Technologische vooruitgang in de pathologie. Een reis door de archieven. Van anatomisch theater naar “gepersonaliseerde geneeskunde”. Deze video presentatie is gemaakt ten behoeve van de promotie van Ronald van Eijk d.d. 8 mei 2013 op het proefschrift: Technological Advances in Molecular Pathology. A journey into the Archives De presentatie geeft een populair wetenschappelijk beeld van de ontwikkelingen in de Pathologie. In de loop der eeuwen zijn er vele revolutionaire, breed...

MWV Episode 72 - Jonathan Eisen - Evolvability, the Built Environment and Open Science

submitted by: MicrobeWorld
Jonathan Eisen is an evolutionary biologist, currently working at University of California, Davis and is the academic editor-in-chief of the open-access journal PLoS Biology. On this episode, Jonathan talks about "evolvability," the probability that organisms can invent new functions. To do this, he has been using genome data in conjunction with experimental information to try and understand the mechanisms by which new functions have originated. Another area of interest for Eisen is the...