Introduction to the scale-invariant organizational phenomenon termed "intelligence crisis".

Computational laboratory: Starting from a set of breast cancer BACs (bacterial artificial chromosomes) End Sequence Profiling (ESP) is performed. ESP analysis sequences the ends of insert DNA in order to characterize genomic rearrangements that may be involved in breast cancer progression. In this study, genomic rearrangements are characterized from 100 breast cancer BACs and 10,000 Fosmids (derived from a pool of the 100 originating BAC) using ESP. Analysis and comparison of both BAC and...

Vortrag über meine Arbeit der letzten Monate am Tag der Anatomie 2008
Talk about my recent work at the "Tag der Anatomie 2008", an inhouse talk-session.

German vodcast about science communications. Diese Woche: Der Astrophysiker Harald Lesch wird Moderator bei ZDF, Joachim Bublath geht. Im März werden neue Folgen von Alpha Centauri produziert - die alten Folgen gibt es bei stage6 oder auf DVD . Diskussion per Webcam: Der "Science Saturday" bei bloggingheads.tv . Für Jugendliche gibt es den Meereswettbewerb 2008 auf dem Forschungsschiff Aldebaran. Stifterverband: Exzellenzinitiative für die Lehre ausgeschrieben. Zwei Preise für...

Insights into cancer biology from the study of basepair-level changes in coding sequences. Genotyping vs. resequencing. Identifying cancer-related genes using association studies. Use of next-generation sequencing technologies to map chromosomal aberrations in cancer genomes. PCR-based resequencing vs. array-based enrichment. Using recurrence, pathway enrichment, and other signatures of positive selection to identify "driver" somatic mutations involved in cancer progression. Part of the...

Lab for the Computer-Aided Discovery Methods course taught at Baylor College of Medicine. Design of an array CGH assay. Finding recurrent aberrations in breast cancer using publicly available array CGH data. Subtracting known human structural polymorphisms. Gene annotation to identify aberrations that involve genes known to be relevant for cancer progression. Identifying aberrations relevant for cancer progression by integrating DNA dosage and gene expression information.