Melanin-concentrating hormone receptor 1 polymorphisms are associated with components of energy balance in the CODING study

submitted by: bfontain
BACKGROUND: The melanin-concentrating hormone receptor 1 (MCHR1) is a G protein-coupled receptor that regulates energy balance and body composition in animal models. Inconsistent effects of MCHR1 polymorphisms on energy homeostasis in humans may partly be attributable to environmental factors. OBJECTIVES: We examined the effect of 4 single nucleotide polymorphisms (rs133073, rs133074, rs9611386, and rs882111) in the MCHR1 gene on body composition as well as energy-related lifestyle...
Authors: Bénédicte Fontaine-Bisson, James Thorburn, Anne Gregory, Hongwei Zhang, Guang Sun

Science Behind the News: Allergies

submitted by: nsf

Seasonal Allergies affect more than 40 million Americans each year. Plant biologist Dr. Kristina Stinson of Harvard University explains how allergies affect the body, and why warmer weather could lead to longer, more severe allergy seasons. "Science Behind the News" is produced in partnership with NBC Learn.

Provided by the National Science Foundation & NBC Learn

Silencing the Menkes Copper-Transporting ATPase (Atp7a) Gene in Rat Intestinal Epithelial (IEC-6) Cells Increases Iron Flux via Transcriptional Induction of Ferroportin 1 (Fpn1)

submitted by: jfcollins
The Menkes copper-transporting ATPase (Atp7a) gene is induced in rat duodenum during iron deficiency, consistent with copper accumulation in the intestinal mucosa and liver. To test the hypothesis that ATP7A influences intestinal iron metabolism, the Atp7a gene was silenced in rat intestinal epithelial (IEC-6) cells using short hairpin RNA (shRNA) technology. Perturbations in intracellular copper homeostasis were noted in knockdown cells, consistent with the dual roles of ATP7A in pumping...
Authors: Sukru Gulec, James F. Collins

Polymorphisms in genes involved in folate metabolism modify the association of dietary and circulating folate and vitamin B-6 with cervical neoplasia

submitted by: LUCIANA TOMITA
High folate intake has been suggested as an important factor for cancer prevention; however, previous studies on the relationship between folate intake, serum folate and plasma homocysteine are controversial. We conducted a hospital-based, case-control study in Brazil investigating associations between dietary and circulating vitamins B-6, B-12 and folate, homocysteine, genotypes of folate-metabolizing enzyme methylenetetrahydrofolate reductase [MTHFR C677T, A1298C],...
Authors: Luciana Tomita, Vania d'Almeida, Luisa Villa, Eduardo Franco, Marly Cardoso

History of Medicine. Plague and Vampirism in the Middle Ages.

submitted by: camdic
The Nachzehrer would be a special kind of vampire who lives in a constant state of numbness in his grave, without understanding what is happening around and just like a child, chewing spasmodically his dress. Martin Böhm wrote in 1601: "We have seen in times of the plague how dead people especially women - who have died of the plague make smacking noises in their graves, like a pig that is eating, and that while this smacking is going on the plague becomes much worse, usually in the...

20131029 - Protein Prediction 2 - Tobias Hamp - Homology Based Prediction of Protein Function

submitted by: rostlab

Date: 20131029

Course: Protein Prediction 2

Title: Homology Based Prediction of Protein Function

Speaker: Tobias Hamp

Audience: Computer Science students