Dynamic Remodeling of Individual Nucleosomes Across a Eukaryotic Genome in Response to Transcriptional Perturbation

submitted by: akshayb
The eukaryotic genome is packaged as chromatin with nucleosomes comprising its basic structural unit, but the detailed structure of chromatin and its dynamic remodeling in terms of individual nucleosome positions has not been completely defined experimentally for any genome. We used ultra-high–throughput sequencing to map the remodeling of individual nucleosomes throughout the yeast genome before and after a physiological perturbation that causes genome-wide transcriptional changes....
Authors: Sushma Shivaswamy, Akshay Bhinge, Yongjun Zhao, Steven Jones, Martin Hirst, Vishwanath r Iyer

Two quick tips to stay on top of literature and other online information using Google

submitted by: simont

Behind in the literature? Losing track of valuable web pages and information you found online? This brief video shows how to use some of Google's free tools, Notebook and Reader, to help you manage these problems. You can use Google Notebook as an online scrapbook to instantly save pieces of text, web pages and even images to your own personal notebook. You can use Google Reader to help you get on top of the literature and then stay on top without any extra effort.

Moby, Legacy Apps and the Semantic Web

submitted by: nodrogluap
[Note: poor video quality lasts only for the first 30 seconds] Presentation given at the Web Services Biohackathon '08 in Tokyo, Japan 2008-02-11. It describes tools for using and providing interoperable bioinformatics Web services. This presentation followed another one outlining the (Bio)Moby protocol and its usage, see www.biomoby.org for more information. Presenter: Paul Gordon .

Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis

submitted by: mmcguckin
Background MUC2 mucin produced by intestinal goblet cells is the major component of the intestinal mucus barrier. The inflammatory bowel disease ulcerative colitis is characterized by depleted goblet cells and a reduced mucus layer, but the aetiology remains obscure. In this study we used random mutagenesis to produce two murine models of inflammatory bowel disease, characterised the basis and nature of the inflammation in these mice, and compared the pathology with human ulcerative colitis....
Authors: Heazlewood CK, Cook MC, Eri R, Price G, Tauro S, Taupin D, Thornton DJ, Png CW, Crockford TL, Cornall, RJ, Adams R, Kato M, Nelms KA, Hong NA, Florin THJ, Goodnow CC, McGuckin MA

HIV/AIDS Education in America (MWV14)

submitted by: MicrobeWorld
In this episode of MicrobeWorld Video we ask some leading researchers, education specialists, and public health officials about the state of HIV/AIDS education in America and ideas they have to support the teaching of microbial evolution using the latest HIV/AIDS research ó all while instilling innovative prevention strategies. Filmed at a forum for educators on February, 11, 2008 at the Koshland Science Museum in Washington, D.C. and at San Diego State University, this episode features...

Temporal Dynamics of European Bat Lyssavirus Type 1 and Survival of Myotis myotis Bats in Natural Colonies

submitted by: Jordi Serra-Cobo
Many emerging RNA viruses of public health concern have recently been detected in bats. However, the dynamics of these viruses in natural bat colonies is presently unknown. Consequently, prediction of the spread of these viruses and the establishment of appropriate control measures are hindered by a lack of information. To this aim, we collected epidemiological, virological and ecological data during a twelve-year longitudinal study in two colonies of insectivorous bats (Myotis myotis)...
Authors: Blanca Amengual, Hervé Bourhy, Marc López-roig, Jordi Serra-cobo