New solution for therapeutic cancer vaccine failure

submitted by: mdanderson Vaccines designed to turn the immune system against cancer have been logically constructed and tested against many cancers. Almost all have failed or shown minimal effect. They spark creation of killer T cells against the cancer, but generally have little effect on tumors, both in patients and mouse models. Willem Overwijk, Ph.D., and colleagues at MD Anderson discovered that a common vaccine component is...

20130131 - Protein Prediction 2 - Marco De Vivo - Paths to drug discovery and the role of computational chemistry

submitted by: rostlab

Date: 20130131
Course: Protein Prediction 2
Title: Paths to drug discovery and the role of computational chemistry
Speaker: Marco De Vivo

20130129 - Protein Prediction 2 - Marco Punta - The Pfam protein families database

submitted by: rostlab

Date: 20130129
Course: Protein Prediction 2
Title: The Pfam protein families database
Speaker: Marco Punta

20130122 - Protein Prediction 2 - Andrea Schafferhans - Docking

submitted by: rostlab

Date: 20130122
Course: Protein Prediction 2
Title: Docking
Speaker: Andrea Schafferhans

Around the Nucleus

submitted by: ahernk

This video is a surreal presentation of a Metabolic Melody by Kevin Ahern ( for more info). The tune is The Beatle's "Across the Universe." The lyrics and video are by Kevin Ahern and the recording is by David Simmons

Endothelin-1 is a transcriptional target of p53 in epidermal keratinocytes and regulates UV induced melanocyte homeostasis

submitted by: arup.indra
Keratinocytes contribute to melanocyte activity by influencing their microenvironment, in part, through secretion of paracrine factors. Here we discovered that p53 directly regulates Edn1 expression in epidermal keratinocytes and controls UV-induced melanocyte homeostasis. Selective ablation of EDN1 in murine epidermis (EDN1ep-/-) does not alter melanocyte homeostasis in newborn skin but decreases dermal melanocytes in adult skin. Results showed that keratinocytic EDN1 in a non-cell...
Authors: Daniel J. Coleman, Gitali Ganguli-Indra, Stephen Hyter, Arup Indra, Steven Ma, Gary F. Merrill, Masashi Yanagisawa