Background The present study was designed to test the hypothesis that inactivation of virtually any component within the pathway containing the BRCA1 and BRCA2 proteins would increase the risks for lymphomas and leukemias. In people who do not have BRCA1 or BRCA2 gene mutations, the encoded proteins prevent breast/ovarian cancer. However BRCA1 and BRCA2 proteins have multiple functions including participating in a pathway that mediates repair of DNA double strand breaks by error-free...

Allele frequency data for the G/A SNP in the coding region of ABCC11 gene in pie-charts displayed on google earth. This SNP determines the earwax type. The human migration pattern image was superimposed on the pie-chart pattern.

Collaboration is a key requirement in several contemporary interventional radiology procedures (IRPs). This work proposes a multicast hybrid satellite system capable of supporting advanced IRP collaboration, and evaluates its feasibility and applicability. Following a detailed IRP requirements study, we have developed a system which supports IRP collaboration through the employment of a hybrid satellite-terrestrial network, a prototype multicast version of wavelet based interactive...

Specific protein associations define the wiring of protein interaction networks and thus control the organization and functioning of the cell as a whole. Peptide recognition by PDZ and other protein interaction domains represents one of the best-studied classes of specific protein associations. However, a mechanistic understanding of the relationship between selectivity and promiscuity commonly observed in the interactions mediated by peptide recognition modules as well as its functional...

MicrobeWorld and the Koshland Science Museum present a video podcast of comedian Brian Malow that includes excerpts from his science comedy act on infectious disease and an interview about the geek mystique of science.

Since the introduction of MSX and Dermo in the 1950’s, two infectious diseases that played a large role in the decline the Chesapeake Bay’s oyster population, several oyster hatcheries along the Eastern seaboard are working with scientists across many fields to develop innovative restoration programs. One idea is to introduce a non-native oyster from China called Crassostrea ariakensis. In this video podcast, MicrobeWorld talks about current research underway with C. ariakensis, the...