Intracellular Parasitism by Trypanosoma cruzi and Leishmania: Part 2: Leishmania spp and Leishmaniasis (13:36)

submitted by: video_collector

In the second part of this lecture, I will present background material on Leishmania, the intracellular protozoan parasites responsible for severe human pathology in several parts of the world. I will discuss the main disease forms, the history of identification of the causative agent and form of transmission, and recent discoveries that established important concepts in our understanding of this increasingly serious infectious disease.

Danger from the Wild: HIV, Can We Conquer It? Part 3: The Grand Challenge: Engineering Immunity (18:51)

submitted by: video_collector
In this last segment, I describe another gene therapy strategy for HIV in which we propose to develop antibody-like proteins that can be expressed by a patient's B cells and will target the HIV virus for destruction. To achieve this objective, hematopoietic (blood) stem cells must to be targeted with the gene, which will ultimately develop into B cells that express the therapeutic molecule. The ultimate goal is to produce a life-long supply of anti-HIV neutralizing antibodies. In this...

Danger from the Wild: HIV, Can We Conquer It?": Part 2: Why Gene Therapy Might be a Reasonable Tool for Attacking HIV (30:08)"

submitted by: video_collector
In part 2, I describe the growing health problem that is facing the world with the spread of HIV and the limitations of current drug therapies and vaccine strategies. We need new ideas for tackling this problem. Here and in the next segment, I describe bold strategies of using gene therapy to conquer HIV, The approach that I describe in this segment involves gene therapy to produce short hairpin RNAs (siRNA) that target the destruction of a critical co-receptor of HIV, which the viruses that...

San Diego Science Festival -- Commercial

submitted by: sdscienccefestival

Commercial running at local SHell stations

Apicomplexan Parasites, Pathogen Genome Informatics, and the Evolution of Eukaryotic Organelles: Part 2: The apicomplexan plastid: Something old, something new, something borrowed, something green (37:11)

submitted by: video_collector
Antibiotics are effective because they kill bacteria without harming humans and other eukaryotes (organisms with cells that contain nuclei). So why are the eukaryotic parasites responsible for malaria and toxoplasmosis killed by drugs like clindamycin? Multidisciplinary studies integrating molecular genetics, cell biology, biochemistry, pharmacology and computational genomics reveal that such drugs target an unusual organelle. The "apicoplast" was acquired when an ancestral organism 'ate' a...

Students Tout Campus Greenness in National Video Competition

submitted by: ucsandiego

Think UC San Diego has one of the coolest sustainability programs around? Now there’s a way to let everyone know. The campus is talking part in the nationwide Chill Out competition organized by the National Wildlife Federation.