Background The glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) evolved from a common ancestor. Still not completely understood is how specificity for glucocorticoids (e.g. cortisol) and mineralocorticoids (e.g. aldosterone) evolved in these receptors. Results Our analysis of several vertebrate GRs and MRs in the context of 3D structures of human GR and MR indicates that with the exception of skate GR, a cartilaginous fish, there is a...

The inception of the "Keeling Curve," a history of atmospheric carbon dioxide levels, marked a key moment in American science history. The record began in March, 1958 at a small observatory on the top of Hawaii's Mauna Loa.

Two lonely chemists sing about their desire for a litmus test for love. Live comedy show performed at the American Society for Human Genetics Annual Meeting

Biological activity in the oceans might make the difference between clear skies and cloudy, Scripps researchers say.

This is an animation to accurately depict results of Eric Stach's (Purdue University) research on the nucleation kinetics of Si nanowires. The visualization shows other scientists how the graph and equations drive the interaction.

After two decades watching atmospheric oxygen levels drop, a Scripps researcher's conclusions about climate could leave one feeling light-headed