Interview with Computational Biologist and SciVee Cofounder Phil Bourne

linked profile(s): simont
submitted by: Phil

Prof. Simon Twigger of the Medical College of Wisconsin asked me to visit for a day in January of 2008. We started the day with this interview which Simon conducted which describes my career and interests. He kindly let us post it here. It might be of interest to anyone considering a career in computational biology as it covers one such career path which began before the field itself was established.

Cheminformatics in Open Notebook Science

submitted by: jcbradley

Jean-Claude Bradley guest lectures on Rajarshi Guha's cheminformatics course at Indiana University. After an introduction to Open Notebook Science and the synthesis of anti-malarial compounds, topics include SMILES, InChIs, InChIKeys, CMLRSS, JCAMP-DX, JSpecView, ExcelVBA, blogs, wikis and Second Life.

HUTCHINSON-GILFORD SYNDROME

submitted by: camdic

Recent studies suggest that, as in other aging syndromes, the Hutchinson-Gilford syndrome is due at to a defect in the mechanism of DNA repair. Mutations have been found in the Lamin A gene (LMNA) situated on chromosome 1.

LASSUEUR PICCARDI GRAHAM LITTLE Syndrome.

submitted by: camdic

A rare disease in which cicatricial (scarring) alopecia of the scalp is associated with widepsread keratosis pilaris particularly in the axillae and pubic area where scarring does not usually occur. The scarring in the scalp may be clinically indistinguishable from the end stage of other forms of scarring hair loss.(Abstract) Prof. Camillo O. Di Cicco,MD

Dynamic Remodeling of Individual Nucleosomes Across a Eukaryotic Genome in Response to Transcriptional Perturbation

submitted by: akshayb
The eukaryotic genome is packaged as chromatin with nucleosomes comprising its basic structural unit, but the detailed structure of chromatin and its dynamic remodeling in terms of individual nucleosome positions has not been completely defined experimentally for any genome. We used ultra-high–throughput sequencing to map the remodeling of individual nucleosomes throughout the yeast genome before and after a physiological perturbation that causes genome-wide transcriptional changes....
Authors: Sushma Shivaswamy, Akshay Bhinge, Yongjun Zhao, Steven Jones, Martin Hirst, Vishwanath r Iyer

Two quick tips to stay on top of literature and other online information using Google

submitted by: simont

Behind in the literature? Losing track of valuable web pages and information you found online? This brief video shows how to use some of Google's free tools, Notebook and Reader, to help you manage these problems. You can use Google Notebook as an online scrapbook to instantly save pieces of text, web pages and even images to your own personal notebook. You can use Google Reader to help you get on top of the literature and then stay on top without any extra effort.