Fibroblasts moving across two-dimensional surfaces form lamellipodial protrusions at their leading edge, but how cells move through three-dimensional environments is less well understood. Petrie et al. reveal that, depending on the strength of intracellular RhoA signaling and on the elastic properties of the extracellular matrix, fibroblasts can migrate through 3D environments using either lamellipodia or blunt, cylindrical protrusions called lobopodia. This biosights episode presents the...

Over-reliance on decontextualized, standardized implementation of eff?cacy evidence has contributed to slow integration of evidence-based interventions into health policy and practice. This article describes an “evidence integration triangle” (EIT) to guide translation, implementation, prevention efforts, comparative effectiveness research, funding, and policy-making. The EIT emphasizes interactions among three related components needed for effective evidence implementation: (1)...

About 20% of colon cancer cases are related to a strong family history of colon cancer. Eduardo Vilar-Sanchez, M.D., Ph.D., Assistant Professor in the Department of Clinical Cancer Prevention at The University of Texas MD Anderson Cancer Center, focuses his discussion on the main types of genetic colon cancers including hereditary nonpolyposis colorectal cancer syndrome or HNPCC (also called Lynch syndrome) and familial adenomatous polyposis (FAP).

Dr. Thomas Gerber, Associate Editor for Mayo Clinic Proceedings, discusses the articles featured on the cover page of the May 2012 issue. These include: •Relationship of Zolpidem and Cancer Risk: A Taiwanese Population-Based Cohort Study, by Dr. Chia Hung Kao and colleagues; and its accompanying editorial, Insomnia, Hypnotic Drug Use, and Patient Well-being: First, Do No Harm, by Dr. Barbara Phillips •Anthropometric Correlates of Total Body Fat, Abdominal Adiposity, and...

Dr. Carola Arndt, a pediatric hematologist from Mayo Clinic in Rochester, MN, discusses her article appearing in the May 2012 issue of Mayo Clinic Proceedings, and reviews the diagnosis, prognosis, staging, multidisciplinary therapy, new directions in therapy,
and long-term complications of treatment for common childhood tumors. Available at:
http://www.mayoclinicproceedings.org/article/S0025-6196(12)00301-1/fulltext

Anil Sood, M.D., discusses research connecting high platelet counts to the severity of ovarian cancer and the Sprint for Life, which raises funds for the Blanton-Davis Ovarian Cancer Research Program.

http://bit.ly/IF7tMG