Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis

submitted by: mmcguckin
Background MUC2 mucin produced by intestinal goblet cells is the major component of the intestinal mucus barrier. The inflammatory bowel disease ulcerative colitis is characterized by depleted goblet cells and a reduced mucus layer, but the aetiology remains obscure. In this study we used random mutagenesis to produce two murine models of inflammatory bowel disease, characterised the basis and nature of the inflammation in these mice, and compared the pathology with human ulcerative colitis....
Authors: Heazlewood CK, Cook MC, Eri R, Price G, Tauro S, Taupin D, Thornton DJ, Png CW, Crockford TL, Cornall, RJ, Adams R, Kato M, Nelms KA, Hong NA, Florin THJ, Goodnow CC, McGuckin MA

HIV/AIDS Education in America (MWV14)

submitted by: MicrobeWorld
In this episode of MicrobeWorld Video we ask some leading researchers, education specialists, and public health officials about the state of HIV/AIDS education in America and ideas they have to support the teaching of microbial evolution using the latest HIV/AIDS research ó all while instilling innovative prevention strategies. Filmed at a forum for educators on February, 11, 2008 at the Koshland Science Museum in Washington, D.C. and at San Diego State University, this episode features...

Temporal Dynamics of European Bat Lyssavirus Type 1 and Survival of Myotis myotis Bats in Natural Colonies

submitted by: Jordi Serra-Cobo
Many emerging RNA viruses of public health concern have recently been detected in bats. However, the dynamics of these viruses in natural bat colonies is presently unknown. Consequently, prediction of the spread of these viruses and the establishment of appropriate control measures are hindered by a lack of information. To this aim, we collected epidemiological, virological and ecological data during a twelve-year longitudinal study in two colonies of insectivorous bats (Myotis myotis)...
Authors: Blanca Amengual, Hervé Bourhy, Marc López-roig, Jordi Serra-cobo

MITOCHONDRIAL DNA LAUNOIS-BENSAUDE's LIPOMATOSIS

submitted by: camdic
Even though Brodie is said to have first described diffuse symmetrical lipomatosis with predilection for the neck already in the 1846 (Clinical Lectures on Surgery, Delivered at St. George's Hospital Philadelphia: Lea and Blanchard pub. Pp 201-201. Brodie, B.C.) still unknown is today the pathogenesis of Launois Bensaude' Lipomatosis. Klopstock et Al. are found in muscle biopsy specimens ragged and red fibers, pathologic subsarcolemmal accumulations of mitochondria, suggesting a...

Homogenization of northern U.S. Great Lakes forests due to land use

submitted by: edtech-isu
Human land use of forested regions has intensified worldwide in recent decades, threatening long-term sustainability. Primary effects include conversion of land cover or reversion to an earlier stage of successional development. Both types of change can have cascading effects through ecosystems; however, the long-term effects where forests are allowed to regrow are poorly understood. We quantify the regional-scale consequences of a century of Euro-American land use in the northern U.S. Great...
Authors: Lisa a. Schulte, David j. Mladenoff, Thomas r. Crow, Laura c. Merrick, David t. Cleland

BEMuSE - protein folding for the grid

submitted by: iSGTW

This video is courtesy of EU-IndiaGrid and shows the setup of a simple simulation using BEMuSE, software for faster folding of proteins using grid computing. (http://euindia.ictp.it/bemuse/video-tutorials/)

This video shows:

* The structure of the restarts
* The configuration of a simulation
* The submission of the jobs