Endothelin-1 is a transcriptional target of p53 in epidermal keratinocytes and regulates UV induced melanocyte homeostasis

submitted by: arup.indra
Keratinocytes contribute to melanocyte activity by influencing their microenvironment, in part, through secretion of paracrine factors. Here we discovered that p53 directly regulates Edn1 expression in epidermal keratinocytes and controls UV-induced melanocyte homeostasis. Selective ablation of EDN1 in murine epidermis (EDN1ep-/-) does not alter melanocyte homeostasis in newborn skin but decreases dermal melanocytes in adult skin. Results showed that keratinocytic EDN1 in a non-cell...
Authors: Daniel J. Coleman, Gitali Ganguli-Indra, Stephen Hyter, Arup Indra, Steven Ma, Gary F. Merrill, Masashi Yanagisawa

Multivitamin-multimineral supplementation and mortality: A meta-analysis of randomized controlled trials

submitted by: mpase
Background: Multivitamins are the most commonly used supplement in the developed world. Recent epidemiological findings suggest multivitamin use increases the risk of mortality. Objectives: We aimed to determine whether multivitamin-multimineral treatment, used for primary or secondary prevention, increases the risk of mortality in independently living adults. Methods: We performed a meta-analysis of randomized, controlled trials. Multiple electronic databases were systematically searched...
Authors: Helen Macpherson, Andrew Pipingas, Matthew Pase

Aptamer Data from Base Pair Biotechnologies

submitted by: BasePairBio

Aptamers have until recently been tightly held by IP restrictions, Base Pair Biotechnologies Founder Bill Jackson presents information and data they have generated on aptmers in diverse assays such as biosensor and lateral flow. Presentation is from the American Society for Cell Biology meeting Dec 16, 2012

The Faith, Activity, and Nutrition Program: A Randomized Controlled Trial in African-American Churches

submitted by: kinnardd
Background: Faith-based interventions hold promise for promoting health in ethnic minority populations. To date, however, few of these interventions have used a community-based participa- tory research (CBPR) approach, have targeted both physical activity and healthy eating, and have focused on structural changes in the church. Purpose: To report the results of a group randomized CBPR intervention targeting physical activity and healthy eating in African-American churches. Design:...
Authors: Cheryl Addy, PhD, Meghan Baruth, PhD, Margaret Condrasky, EdD, Marsha Dowda, DrPH, Rebecca Evans, MDiv, Deborah Kinnard, Marilyn Laken, PhD, Allen Parrott, DMin, Tatiana Warren, MS, Sara Wilcox, PhD, Lakisha Zimmerman, MSW, MA

Three new drugs increase options for CML patients

submitted by: mdanderson

Jorge Cortes, M.D., discusses how ponatinib, bosutinib and omacetaxine, approved by the FDA recently, can help chronic myeloid leukemia patients.

Opera singer Pablo Romero sings with the MD Anderson employee choir

submitted by: mdanderson

Opera singer Pablo Romero sang with the MD Anderson employee choir on December 19th, 2012. In this video, he performs favorite Christmas songs.