Silencing the Menkes Copper-Transporting ATPase (Atp7a) Gene in Rat Intestinal Epithelial (IEC-6) Cells Increases Iron Flux via Transcriptional Induction of Ferroportin 1 (Fpn1)

submitted by: jfcollins
The Menkes copper-transporting ATPase (Atp7a) gene is induced in rat duodenum during iron deficiency, consistent with copper accumulation in the intestinal mucosa and liver. To test the hypothesis that ATP7A influences intestinal iron metabolism, the Atp7a gene was silenced in rat intestinal epithelial (IEC-6) cells using short hairpin RNA (shRNA) technology. Perturbations in intracellular copper homeostasis were noted in knockdown cells, consistent with the dual roles of ATP7A in pumping...
Authors: Sukru Gulec, James F. Collins

20131022 - Protein Prediction 2 - Burkhard Rost - Individual Health

submitted by: rostlab

Date: 20131022

Course: Protein Prediction 2

Title: Individual Health

Speaker: Burkhard Rost

Audience: Computer Science students

20131022 - Protein Prediction 2 - Burkhard Rost - Individual Health

submitted by: rostlab

Date: 20131022

Course: Protein Prediction 2

Title: Individual Health

Speaker: Burkhard Rost

Audience: Computational Biology students

MWV Episode 76 - Jeffrey Almond - Vaccine Development

submitted by: MicrobeWorld
Dr. Jeffrey Almond began his career as an academic virologist studying influenza. Eventually Jeffrey started his own lab and began studying picornaviruses working on an oral polio vaccine strain. Following twenty years in academics including major contributions in the eradication of polio worldwide, Jeffrey transitioned into a career in industry working on vaccine development at Sanofi Pasteur. In March of 2013, Jeffrey was at the Society for General Microbiology's Spring conference to...

Meeting the Challenges of Food Security with Biotechnology

submitted by: UP Los Baños

Documentation of the special seminar on "Meeting the Challenges of Food Security with Biotechnology," by Mark Lynas, Author, Environmental Campaigner, and Visiting Research Associate 
School of Geography and the Environment, Oxford University, United Kingdom last 23 August 2013 at SEARCA, UPLB, College, Laguna| 130 MB | 33 mins

A diet rich in high glucoraphanin broccoli interacts with genotype to reduce discordance in plasma metabolite profiles through modulating mitochondrial function

submitted by: Andrew Chapple
Background: Observational and experimental studies suggest that diets rich in cruciferous vegetables and glucosinolates may reduce the risk of cancer and cardiovascular disease (CVD). Objective: We tested the hypothesis that a 12-wk dietary intervention with high-glucoraphanin (HG) broccoli would modify biomarkers of CVD risk and plasma metabolite profiles to a greater extent than interventions with standard broccoli or peas. Design: Subjects were randomly assigned to consume 400 g...
Authors: Charlotte Armah, Maria Traka, Jack Dainty, Marianne Defernez, Astrid Janssens, Wing Leung, John Potter, Richard Mithen