Small Regulatory RNAs May Sharpen Spatial Expression Patterns

linked profile(s): hlevine
submitted by: apryl
The precise establishment of gene expression patterns is a crucial step in development. Formation of a sharp boundary between high and low spatial expression domains requires a genetic mechanism that exhibits sensitivity, yet is robust to fluctuations, a demand that may not be easily achieved by morphogens alone. Recently, it has been demonstrated that small RNAs (and, in particular, microRNAs) play many roles in embryonic development. Whereas some RNAs are essential for embryogenesis,...
Authors: Erel Levine, Peter Mchale, Herbert Levine

Sleeping Beauty Invades Rat's Genome

submitted by: simont
Knockouts are not just for Mice anymore. Aron Geurts and Howard Jacob from the Medical College of Wisconsin talk about their plans for creating transgenic rats using the Sleeping beauty transposon. Coming out of work pioneered by Colin Bishop's lab, Geurts and Jacob describe how the Sleeping Beauty system can be used to make transgenic rats and their plans to make the phenotype data from these rats available via the MCW PGA website ( http://pga.mcw.edu ) and the strains themselves accessible...

Is there preferential loss of aortic baroreceptor C-fibre activity during the development of atherosclerosis?

submitted by: Mike_Turner

Michael Turner shares his poster presentation at the Experimental Biology 2008 conference.

Resident cardiac mast cells contribute to ischemia-reperfusion injury in the isolated, perfused mouse heart

submitted by: trork314

Tyler Rork shares his poster presentation at the Experimental Biology 2008 conference