Endothelin-1 is a transcriptional target of p53 in epidermal keratinocytes and regulates UV induced melanocyte homeostasis

submitted by: arup.indra
Keratinocytes contribute to melanocyte activity by influencing their microenvironment, in part, through secretion of paracrine factors. Here we discovered that p53 directly regulates Edn1 expression in epidermal keratinocytes and controls UV-induced melanocyte homeostasis. Selective ablation of EDN1 in murine epidermis (EDN1ep-/-) does not alter melanocyte homeostasis in newborn skin but decreases dermal melanocytes in adult skin. Results showed that keratinocytic EDN1 in a non-cell...
Authors: Daniel J. Coleman, Gitali Ganguli-Indra, Stephen Hyter, Arup Indra, Steven Ma, Gary F. Merrill, Masashi Yanagisawa

Systems as the Driver for Synthetic Biology

submitted by: RASEIBoulder
We now possess the ability to read and write DNA. These tools are not only revolutionizing biotechnology but also the basic life sciences as well. The challenge is that we are still learning the grammar. In other words, we often do not know which genetic perturbations to make in order to alter the behavior of an organism. As a result, synthetic biology still involves much trial and error. Moreover, we are still far from the point where we can engineer new organisms from scratch – rather,...

Building Public Trust in Uses of HIPAA De-Identified Date

submitted by: Jamia

The aim is to build public trust. Without privacy protection, people will aboid having their data shared. Their goal is to identify which concerns are "real" and begin discussion on how to resolve those concerns.

Aptamer Data from Base Pair Biotechnologies

submitted by: BasePairBio

Aptamers have until recently been tightly held by IP restrictions, Base Pair Biotechnologies Founder Bill Jackson presents information and data they have generated on aptmers in diverse assays such as biosensor and lateral flow. Presentation is from the American Society for Cell Biology meeting Dec 16, 2012

Biochemist - Profiles of Scientists and Engineers

submitted by: nsf

What's it really like to be an engineer or a scientist? What do they really do all day? You're about to find out! Meet the next generation of engineers and scientists in these profiles of young professionals, who may just inspire you to join them. Roselle Rojas shows us some of the latest biochemistry projects taking place at Gatorade's Sport Science Institute and what her typical day is like inside and outside the lab.

Foraging Strategies for Starving and Feeding Amoeba

submitted by: icamvid

Foraging Strategies for Starving and Feeding Amoeba by Simon Norrelykke, Princeton University, USA
Soft Active Materials
May 18, 2009 – May 21, 2009
Syracuse University, New York