The Nature Explorers Cibola Expedition Part 1 of 5

submitted by: thenatureexplorers

Located on the Arizona and California border along the southern Colorado River, the river provides an oasis in arid desert to the migrating birds flying south along the Pacific Flyway to Central and South America and is a habitat as well for many other animals such as feral donkeys, raccoons, lizards, chipmunks, and more.

20130122 - Protein Prediction 2 - Andrea Schafferhans - Docking

submitted by: rostlab

Date: 20130122
Course: Protein Prediction 2
Title: Docking
Speaker: Andrea Schafferhans

biosights: January 21, 2013 - How cell shape changes unfold

submitted by: JCB
Under certain conditions, cells form protrusions that oscillate rapidly around the cell periphery. Kapustina et al. reveal that these oscillatory protrusions, which may be related to processes involved in amoeboid cell migration, are driven by the cyclic folding and unfolding of the plasma membrane and its underlying actin cortex. This biosights episode presents the paper by Kapustina et al. from the January 7, 2013, issue of The Journal of Cell Biology and includes an interview with lead...

Around the Nucleus

submitted by: ahernk

This video is a surreal presentation of a Metabolic Melody by Kevin Ahern ( for more info). The tune is The Beatle's "Across the Universe." The lyrics and video are by Kevin Ahern and the recording is by David Simmons

Endothelin-1 is a transcriptional target of p53 in epidermal keratinocytes and regulates UV induced melanocyte homeostasis

submitted by: arup.indra
Keratinocytes contribute to melanocyte activity by influencing their microenvironment, in part, through secretion of paracrine factors. Here we discovered that p53 directly regulates Edn1 expression in epidermal keratinocytes and controls UV-induced melanocyte homeostasis. Selective ablation of EDN1 in murine epidermis (EDN1ep-/-) does not alter melanocyte homeostasis in newborn skin but decreases dermal melanocytes in adult skin. Results showed that keratinocytic EDN1 in a non-cell...
Authors: Daniel J. Coleman, Gitali Ganguli-Indra, Stephen Hyter, Arup Indra, Steven Ma, Gary F. Merrill, Masashi Yanagisawa

Systems as the Driver for Synthetic Biology

submitted by: RASEIBoulder
We now possess the ability to read and write DNA. These tools are not only revolutionizing biotechnology but also the basic life sciences as well. The challenge is that we are still learning the grammar. In other words, we often do not know which genetic perturbations to make in order to alter the behavior of an organism. As a result, synthetic biology still involves much trial and error. Moreover, we are still far from the point where we can engineer new organisms from scratch – rather,...