Melanin-concentrating hormone receptor 1 polymorphisms are associated with components of energy balance in the CODING study

submitted by: bfontain
BACKGROUND: The melanin-concentrating hormone receptor 1 (MCHR1) is a G protein-coupled receptor that regulates energy balance and body composition in animal models. Inconsistent effects of MCHR1 polymorphisms on energy homeostasis in humans may partly be attributable to environmental factors. OBJECTIVES: We examined the effect of 4 single nucleotide polymorphisms (rs133073, rs133074, rs9611386, and rs882111) in the MCHR1 gene on body composition as well as energy-related lifestyle...
Authors: Bénédicte Fontaine-Bisson, James Thorburn, Anne Gregory, Hongwei Zhang, Guang Sun

biosights: January 20, 2014 - Motors give a new twist to platelet activation

submitted by: JCB
The discoid shape of resting platelets is maintained by a peripheral ring of bundled microtubules called the marginal band. Diagouraga et al. reveal that, upon platelet activation, the motor protein dynein slides microtubules apart, inducing marginal band coiling and the conversion of platelets to a spherical shape. This biosights episode presents the paper by Diagouraga et al. from the January 20, 2014, issue of The Journal of Cell Biology and includes an interview with senior author Karin...

New Species of Sea Anemone Discovered by NSF Scientists in Antarctica

submitted by: nsf
During a routine test of an underwater robot, NSF scientists from University of Nebraska-Lincoln made a startling discovery...an entirely new species of sea anemone living inside the ice. For more information, visit http://www.nsf.gov/news/news_summ.jsp?cntn_id=130117&org=NSF&from=news

Science Behind the News: Bio-inspired Materials

submitted by: nsf

In the search for the next groundbreaking tough material, scientists like David Kisalus from the University of California, Riverside are looking to nature for inspiration, including under the sea where one little crustacean packs a walloping punch - the peacock mantis shrimp.

Provided by the National Science Foundation & NBC Learn

Science Behind the News: Allergies

submitted by: nsf

Seasonal Allergies affect more than 40 million Americans each year. Plant biologist Dr. Kristina Stinson of Harvard University explains how allergies affect the body, and why warmer weather could lead to longer, more severe allergy seasons. "Science Behind the News" is produced in partnership with NBC Learn.

Provided by the National Science Foundation & NBC Learn

Silencing the Menkes Copper-Transporting ATPase (Atp7a) Gene in Rat Intestinal Epithelial (IEC-6) Cells Increases Iron Flux via Transcriptional Induction of Ferroportin 1 (Fpn1)

submitted by: jfcollins
The Menkes copper-transporting ATPase (Atp7a) gene is induced in rat duodenum during iron deficiency, consistent with copper accumulation in the intestinal mucosa and liver. To test the hypothesis that ATP7A influences intestinal iron metabolism, the Atp7a gene was silenced in rat intestinal epithelial (IEC-6) cells using short hairpin RNA (shRNA) technology. Perturbations in intracellular copper homeostasis were noted in knockdown cells, consistent with the dual roles of ATP7A in pumping...
Authors: Sukru Gulec, James F. Collins