A General Definition and Nomenclature for Alternative Splicing Events

submitted by: micha
Understanding the molecular mechanisms responsible for the regulation of the transcriptome present in eukaryotic cells is one of the most challenging tasks in the postgenomic era. In this regard, alternative splicing (AS) is a key phenomenon contributing to the production of different mature transcripts from the same primary RNA sequence. As a plethora of different transcript forms is available in databases, a first step to uncover the biology that drives AS is to identify the different...
Authors: Michael Sammeth, Sylvain Foissac, Roderic Guigó

Rethinking proteasome evolution: two novel bacterial proteasomes.

linked profile(s): Phil
submitted by: drnknmstrr
The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes. Despite this variation in complexity, all the proteasomes are composed of homologous subunits. We...
Authors: Valas Re, Bourne Pe

Heart Simulator

submitted by: lobosco
Over the last few years, computer models have become valuable tools for the understanding of the multi-scale and multi-physics phenomena that underlie the complex biophysical structures and processes of the heart. Our current computational models track the electro-mechanics of the heart from sub-cellular to the whole-organ level. Therefore, the models allow a better comprehension of important cardiac diseases, such as Ventricular Arrhythmia, Myocarditis, Infarct, Chagas Disease, Diabetes,...

The One Health Initiative MWV18

submitted by: MicrobeWorld
Ronald Atlas, former President for the American Society for Microbiology, discusses the new One Health Initiative that recognizes the inter-relationships among human, animal, and environmental health and seeks to enhance communication, cooperation, and collaboration in integrating these areas for the health and well-being of all species. Development of the One Health Initiative began in 2007 with the American Veterinary Medical Association's (AVMA) efforts to strengthen communications and...