biosights: December 22, 2014 - Osmotic gradient is just the tonic for wounded epithelia

submitted by: JCB
Rapid wound repair is generally thought to be initiated by intrinsic cues, such as changes in the structure or mechanics of damaged tissues. Gault et al. reveal that an extrinsic signal — the osmolarity of the external environment — can stimulate wound closure in zebrafish by inducing epithelial cell migration. This biosights episode presents the paper by Gault et al. from the December 22, 2014, issue of The Journal of Cell Biology and includes an interview with the paper's senior...

Avian Phylogenomics Consortium report details origins of bird species

submitted by: nsf
In a landmark study that researched the origins of bird species, evolutionary biologists have made discoveries about the age of birds, and the genomic relationships among modern birds. The genomes of modern birds tell a story: today's winged rulers of the skies emerged and evolved after the mass extinction that wiped out dinosaurs and almost everything else 66 million years ago. That story is now coming to light, thanks to an international collaboration that has been underway for four...

Conserving biodiversity in Central Africa

submitted by: nsf
The Congo basin is an unruly ribbon of tropical forest, over a million square miles spanning six countries in Central Africa. It is the second-largest contiguous tropical forest in the world. The basin is home to the classics of African wildlife – chimpanzees, elephants, gorillas – along with thousands of other less well-known species. This wealth of flora and fauna, much of it native to the region, is enough to qualify the Congo basin as a biodiversity hotspot: a biologically rich...

biosights: November 24, 2014 - Dynein helps centrioles stick together

submitted by: JCB
Dynein has numerous functions in mitosis, but the function of the motor complex's light intermediate chains is poorly understood. Jones et al. reveal that dynein's light intermediate chains are required to maintain centrosome integrity during mitosis, preventing the premature separation of mother-daughter centrioles and the formation of multipolar spindles. This biosights episode presents the paper by Jones et al. from the November 24, 2014, issue of The Journal of Cell Biology and includes...

biosights: October 27, 2014 - Epithelial cells make changes at the top

submitted by: JCB
The apical surfaces of polarized epithelia are covered by short, actin-rich protrusions called microvilli, but what happens to these structures when cells detach from a monolayer during development or disease is unclear. Klingner et al. reveal that non-confluent epithelial cells form longer, more dynamic microvilli on their apical surface that connect to a cortical actomyosin network. This biosights episode presents the paper by Klingner et al. from the October 13, 2014, issue of The Journal...

Cognitive Heart Failure explained via 3D Animation

submitted by: Scientific Animations

CHF or Congestive Heart Failure, a condition on continuos rise explained - Are lifestyle changes responsible for increase in cases of CHF? What are the main causes? Economic impact on health system? Innovations in diagnosing and treating CHF?
Medical Industry Trends for CHF