biosights: April 13, 2015 - A motif that helps myosin II-B lead from behind

submitted by: JCB
Myosin II-A and myosin II-B play distinct roles in establishing the front–back polarity of migrating mesenchymal cells. Juanes-Garcia et al. identify a short, serine-rich motif in the non-helical tail domain of myosin II-B that enables this isoform to form stable actomyosin bundles that define the cell rear. This biosights episode presents the paper by Juanes-Garcia et al. from the April 13, 2015, issue of The Journal of Cell Biology and includes an interview with the paper's senior...

Mar 20, 2015; iDASH External Webinar; Amalio Telenti

submitted by: ucsd_idash
Privacy issues when looking for a needle in a genomic haystack Amalio Telenti Human Longevity Inc. Abstract: Very rare single nucleotide variants are the most prevalent form of genetic diversity in the human population. Such variants are generally refered to as Variants of Unknown Significance (VUS). It is expected that VUS will attract increasing attention of the medical services as possibly associated with clinical disease or disease predisposition. The considerations above call...

biosights: March 16, 2015 - PAPC separates tissues at a Snail's pace

submitted by: JCB
Brachet's cleft separates the ectoderm and mesoderm of early Xenopus and zebrafish embryos. Luu et al. reveal that, in conjunction with the transcription factor Snail1, the protocadherin PAPC promotes tissue separation by down-regulating planar cell polarity proteins at the ectoderm-mesoderm boundary. This biosights episode presents the paper by Luu et al. from the March 16, 2015, issue of The Journal of Cell Biology and includes an interview with one of the paper's senior authors, Rudolf...

Minimally invasive surgery treating cancer

submitted by: mdanderson
Minimally invasive, or endoscopic, surgery takes advantage of advances in computer imaging and robotics to provide effective surgical cancer treatment with a much smaller impact on the patient. Surena Matin, M.D., medical director of the Minimally Invasive and New Technology in Oncologic Surgery (MINTOS) Collaborative Group at MD Anderson Cancer Center, discusses treatment options using this treatment option for diseases such as prostate cancer, kidney cancer, bladder cancer and gynecologic...

biosights: February 16, 2015 - Filopodia point the way for haptotaxis

submitted by: JCB
Migrating fibroblasts maintain or change their direction by branching off new lamellipodia from existing protrusions at the cell's leading edge. Johnson et al. reveal that filopodial protrusions initiate and orient these lamellipodia, helping fibroblasts navigate gradients of immobilized guidance cues. This biosights episode presents the paper by Johnson et al. from the February 16, 2015, issue of The Journal of Cell Biology and includes an interview with the paper's senior author, Jason...

biosights: January 19, 2015 - Tubulin transport pumps up cilia

submitted by: JCB
The assembly of cilia and flagella requires the delivery of large amounts of tubulin to the growing ends of the organelles' microtubules. Craft et al. reveal that tubulin loading onto intraflagellar transport particles is specifically upregulated in growing cilia. This biosights episode presents the paper by Craft et al. from the January 19, 2015, issue of The Journal of Cell Biology and includes an interview with the paper's senior author, Karl Lechtreck (University of Georgia, Athens, GA)....