A semaphorin code defines subpopulations of spinal motor neurons during mouse development.

linked profile(s): lydiane
submitted by: apryl
In the spinal cord, motor neurons (MNs) with similar muscle targets and sensory inputs are grouped together into motor pools. To date, relatively little is known about the molecular mechanisms that control the establishment of pool-specific circuitry. Semaphorins, a large family of secreted and cell surface proteins, are important mediators of developmental processes such as axon guidance and cell migration. Here, we used mRNA in situ hybridization to study the expression patterns of...
Authors: Henderson Ce, Mann F., Rougon G, Livet J, Funkelstein L, Cohen S, Castellani V

Functional and Structural Insights Revealed by Molecular Dynamics Simulations of an Essential RNA Editing Ligase in Trypanosoma

linked profile(s): Rommie, SDSC
submitted by: apryl
RNA editing ligase 1 (TbREL1) is required for the survival of both the insect and bloodstream forms of Trypanosoma brucei, the parasite responsible for the devastating tropical disease African sleeping sickness. The type of RNA editing that TbREL1 is involved in is unique to the trypanosomes, and no close human homolog is known to exist. In addition, the high-resolution crystal structure revealed several unique features of the active site, making this enzyme a promising target for...
Authors: Rommie e. Amaro, Robert v. Swift, J. andrew Mccammon

UCSD Organic Lab: Extraction

submitted by: joshuakrohn

A Lab training video on how to separate organic and aqueous compounds through solvent extraction.

UCSD Organic Lab: Distillation

submitted by: joshuakrohn

Training Video for Lab

UCSD Organic Lab: MicroRecrystallization

submitted by: joshuakrohn

Training Video for Lab

Computation Enabling Bio-Science & Engineering

submitted by: SDSC

Prof. Andy McCammon, Biochemistry, UCSD discusses "Computation Enabling Bio-Science & Engineering" at the Cyberinfrastructure Experiences for Graduate Students Spring Orientation Workshop in 2007. For more information see: http://www.sdsc.edu/us/training/index.html