Preservation of adaptive plasticity across scales of biological organization: from molecules to societies

submitted by: akourakine

This webcast outlines why and how adaptive plasticity is maintained at each and every scale of biological organization

The BRCA1/2 pathway prevents hematologic cancers in addition to breast and ovarian cancers

submitted by: BernardFriedenson
Background The present study was designed to test the hypothesis that inactivation of virtually any component within the pathway containing the BRCA1 and BRCA2 proteins would increase the risks for lymphomas and leukemias. In people who do not have BRCA1 or BRCA2 gene mutations, the encoded proteins prevent breast/ovarian cancer. However BRCA1 and BRCA2 proteins have multiple functions including participating in a pathway that mediates repair of DNA double strand breaks by error-free...
Authors: Bernard Friedenson

The PDZ Domain as a Complex Adaptive System

submitted by: akourakine
Specific protein associations define the wiring of protein interaction networks and thus control the organization and functioning of the cell as a whole. Peptide recognition by PDZ and other protein interaction domains represents one of the best-studied classes of specific protein associations. However, a mechanistic understanding of the relationship between selectivity and promiscuity commonly observed in the interactions mediated by peptide recognition modules as well as its functional...
Authors: Alexei Kurakin, Andrzej Swistowski, Susan c. Wu, Dale e. Bredesen

Brian Malow - Live at the Koshland

submitted by: MicrobeWorld

MicrobeWorld and the Koshland Science Museum present a video podcast of comedian Brian Malow that includes excerpts from his science comedy act on infectious disease and an interview about the geek mystique of science.

Part 1: Simulating Solidification in Metals at HIgh Pressure

submitted by: SDSC

Dr. Fred Streitz of Lawrence Livermore National Laboratory gives the Keynote Address at The 2006 Summer Computing Institute. For more information about the Summer Institute please visit: http://www.sdsc.edu/us/training/workshops/2006summerinstitute/index.html. Originally posted on SDSC's CI Channel

Part 2: Simulating Solidification in Metals at HIgh Pressure

submitted by: SDSC

Dr. Fred Streitz of Lawrence Livermore National Laboratory gives the Keynote Address at The 2006 Summer Computing Institute. For more information about the Summer Institute please visit: http://www.sdsc.edu/us/training/workshops/2006summerinstitute/index.html. Originally posted on SDSC's CI Channel