The inception of the "Keeling Curve," a history of atmospheric carbon dioxide levels, marked a key moment in American science history. The record began in March, 1958 at a small observatory on the top of Hawaii's Mauna Loa.
Insights into cancer biology from the study of basepair-level changes in coding sequences. Genotyping vs. resequencing. Identifying cancer-related genes using association studies. Use of next-generation sequencing technologies to map chromosomal aberrations in cancer genomes. PCR-based resequencing vs. array-based enrichment. Using recurrence, pathway enrichment, and other signatures of positive selection to identify "driver" somatic mutations involved in cancer progression. Part of the...
Lab for the Computer-Aided Discovery Methods course taught at Baylor College of Medicine. Design of an array CGH assay. Finding recurrent aberrations in breast cancer using publicly available array CGH data. Subtracting known human structural polymorphisms. Gene annotation to identify aberrations that involve genes known to be relevant for cancer progression. Identifying aberrations relevant for cancer progression by integrating DNA dosage and gene expression information.
