Defining UPLB’s Role in Philippine Plant Natural Products’ Research and Development in the Early 21st Century

submitted by: UP Los Baños

Documentation of the UPLB Centennial Professorial Lecture on "Defining UPLB’s Role in Philippine Plant Natural Products’ Research and Development in the Early 21st Century" by Dr. Lourdes B. Cardenas, Professor, Institute of Biological Sciences, College of Arts and Sciences, UP Los Baños on February 26, 2013 at the SEARCA Drilon Hall, UPLB, College, Laguna, Philippines.

20130131 - Protein Prediction 2 - Marco De Vivo - Paths to drug discovery and the role of computational chemistry

submitted by: rostlab

Date: 20130131
Course: Protein Prediction 2
Title: Paths to drug discovery and the role of computational chemistry
Speaker: Marco De Vivo

20130122 - Protein Prediction 2 - Andrea Schafferhans - Docking

submitted by: rostlab

Date: 20130122
Course: Protein Prediction 2
Title: Docking
Speaker: Andrea Schafferhans

Around the Nucleus

submitted by: ahernk

This video is a surreal presentation of a Metabolic Melody by Kevin Ahern (www.davincipress.com/metabmelodies.html for more info). The tune is The Beatle's "Across the Universe." The lyrics and video are by Kevin Ahern and the recording is by David Simmons

Endothelin-1 is a transcriptional target of p53 in epidermal keratinocytes and regulates UV induced melanocyte homeostasis

submitted by: arup.indra
Keratinocytes contribute to melanocyte activity by influencing their microenvironment, in part, through secretion of paracrine factors. Here we discovered that p53 directly regulates Edn1 expression in epidermal keratinocytes and controls UV-induced melanocyte homeostasis. Selective ablation of EDN1 in murine epidermis (EDN1ep-/-) does not alter melanocyte homeostasis in newborn skin but decreases dermal melanocytes in adult skin. Results showed that keratinocytic EDN1 in a non-cell...
Authors: Daniel J. Coleman, Gitali Ganguli-Indra, Stephen Hyter, Arup Indra, Steven Ma, Gary F. Merrill, Masashi Yanagisawa

Systems as the Driver for Synthetic Biology

submitted by: RASEIBoulder
We now possess the ability to read and write DNA. These tools are not only revolutionizing biotechnology but also the basic life sciences as well. The challenge is that we are still learning the grammar. In other words, we often do not know which genetic perturbations to make in order to alter the behavior of an organism. As a result, synthetic biology still involves much trial and error. Moreover, we are still far from the point where we can engineer new organisms from scratch – rather,...