Endothelin-1 is a transcriptional target of p53 in epidermal keratinocytes and regulates UV induced melanocyte homeostasis

submitted by: arup.indra
Keratinocytes contribute to melanocyte activity by influencing their microenvironment, in part, through secretion of paracrine factors. Here we discovered that p53 directly regulates Edn1 expression in epidermal keratinocytes and controls UV-induced melanocyte homeostasis. Selective ablation of EDN1 in murine epidermis (EDN1ep-/-) does not alter melanocyte homeostasis in newborn skin but decreases dermal melanocytes in adult skin. Results showed that keratinocytic EDN1 in a non-cell...
Authors: Daniel J. Coleman, Gitali Ganguli-Indra, Stephen Hyter, Arup Indra, Steven Ma, Gary F. Merrill, Masashi Yanagisawa

Systems as the Driver for Synthetic Biology

submitted by: RASEIBoulder
We now possess the ability to read and write DNA. These tools are not only revolutionizing biotechnology but also the basic life sciences as well. The challenge is that we are still learning the grammar. In other words, we often do not know which genetic perturbations to make in order to alter the behavior of an organism. As a result, synthetic biology still involves much trial and error. Moreover, we are still far from the point where we can engineer new organisms from scratch – rather,...

20130115 - Protein Prediction 2 - Andrea Schafferhans - Protein Ligand Interactions

submitted by: rostlab

Date: 20130115
Course: Protein Prediction 2
Title: Protein Ligand Interactions
Speaker: Andrea Schafferhans

20130108 - Protein Prediction 2 - Burkhard Rost - Predict protein interactions 1

submitted by: rostlab

Date: 20130108
Course: Protein Prediction 2
Title: Predict protein interactions 1
Speaker: Burkhard Rost

20121218 - Protein Prediction 2 - Andrea Schafferhans - Enzymes

submitted by: rostlab

Date: 20121218
Course: Protein Prediction 2
Title: Enzymes
Speaker: Andrea Schafferhans

Aptamer Data from Base Pair Biotechnologies

submitted by: BasePairBio

Aptamers have until recently been tightly held by IP restrictions, Base Pair Biotechnologies Founder Bill Jackson presents information and data they have generated on aptmers in diverse assays such as biosensor and lateral flow. Presentation is from the American Society for Cell Biology meeting Dec 16, 2012